منابع مشابه
Apolipoprotein E and Alzheimer disease.
Inheritance of specific apolipoprotein E (apoE) alleles determines, in large part, the risk and mean age of onset of late-onset familial and sporadic Alzheimer disease. The mechanism by which the apoE isoforms differentially contribute to disease expression is, however, unknown. Isoform-specific differences have been identified in the binding of apoE to the microtubule-associated protein tau, w...
متن کاملApolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease.
Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease (AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system (CNS), apoE is produced by glial cells, is present in high-density-like lipoproteins, interacts with several receptors that are members of the low-density lipoprotein receptor (LDLR) family, and is a protein tha...
متن کاملCerebrovascular effects of apolipoprotein E: implications for Alzheimer disease.
Human apolipoprotein E (apoE) has 3 isoforms: apoE2, apoE3, and apoE4. APOE4 is a major genetic risk factor for Alzheimer disease and is associated with dementia in Down syndrome and poor neurological outcome after traumatic brain injury, cerebral hemorrhage, and other neuropathological disorders. While apoE4 can induce neuropathology by participating in various cellular and molecular pathways,...
متن کاملVitamin E and Alzheimer Disease
Introduction Recently, there has been growing interest in the use of vitamins for the treatment of various health conditions. One study has estimated that 35–54% of older Canadians take some form of vitamin or mineral supplement.1 Oxidative stress has been theorized to be an important contributor to select conditions, particularly those involving the cardiovascular and central nervous systems. ...
متن کاملGenotypes and phenotypes for apolipoprotein E and Alzheimer disease in the Honolulu-Asia aging study.
BACKGROUND The utility of apolipoprotein E (ApoE) type as an indicator of genetic susceptibility to Alzheimer disease (AD) depends on the reliability of typing. Although ApoE protein isoform phenotyping is generally assumed equivalent to genotyping from DNA, phenotype-genotype differences have been reported. METHODS ApoE genotype and phenotype results were examined for 3564 older (ages 71-93 ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1995
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.92.11.4725